C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) A61K 38/17 (2006.01) A61K 38/35 (2006.01) A61P 5/00 (2006.01) C07K 14/695 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2597065
The present invention is directed to compositions and methods related to soluble G-protein coupled receptors (sGPCR). In ceratin aspects the invention includes compositions and methods related to a soluble corticotropin releasing factor receptor related protein, sCRFR2, as well as its effects on CRFR signaling and interaction between CRF family ligand and CRFR receptors, including but not limited to CRFR2, CRFRl and functional or signaling capable variants thereof.
La présente invention concerne des compositions et des méthodes se rapportant aux récepteurs couplés à la protéine G soluble (sGPCR). Dans certains aspects, l'invention concerne des compositions et des méthodes se rapportant à une protéine associée aux récepteurs du facteur de libération de la corticotropine soluble, sCRFR2, ainsi que ses effets sur la signalisation de CRFR et l'interaction entre un ligand de la famille de CRF et des récepteurs CRFR, comprenant mais ne se limitant pas aux CRFR2, CRFR1 et aux variants de ces derniers présentant une capacité fonctionnelle et de signalisation.
Chen Alon
Perrin Marilyn
Vale Wylie
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Research Development Foundation
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