A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01)
Patent
CA 2637598
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacteria. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a secreted virulence factor, which may be EsxA and/or EsxB, and/or peptide processed by sortase, which may be SdrD, SdrE, IsdA, IsdB SdrC, Spa, IsdC, CIfA, CIfB, SasF, or combinations thereof.
La présente invention concerne des procédés et des compositions pour traiter ou prévenir une infection bactérienne, notamment une infection par des bactéries Staphylococcus. L'invention concerne des procédés et des compositions pour stimuler une réponse immunitaire contre les bactéries. Dans certains modes de réalisation, les procédés et les compositions incluent un facteur de virulence sécrété, qui peut être EsxA et/ou EsxB, et/ou un peptide traité par la sortase, qui peut être SdrD, SdrE, IsdA, IsdB SdrC, Spa, IsdC, CIfA, CIfB, SasF, ou des combinaisons de ceux-ci.
Burts Monica
Missiakas Dominique
Schneewind Olaf
Stranger-Jones Yukiko
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Of Chicago
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