A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2474497
The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.
Cette invention concerne des compositions et des méthodes permettant de promouvoir ou de réduire la circulation de lymphocytes T vers un tissu cible. Cette invention concerne également des compositions et des méthodes permettant de promouvoir ou d'inhiber l'activation de cellules de présentation de l'antigène (APC). Cette invention porte sur la découverte de caractéristiques fonctionnelles de TIM-3 qui est une molécule de préférence exprimée sur la surface de cellules Th1. Ces méthodes servent à traiter des troubles tels que le cancer, les maladies infectieuses, les allergies, l'asthme et les maladies auto-immunes.
Freeman Gordon J.
Gaglia Jason L.
Greenfield Edward A.
Kuchroo Vijay K.
Monney Laurent
Brigham And Women's Hospital Inc.
Dana-Farber Cancer Institute Inc.
Smart & Biggar
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