Compositions and methods related to toll-like receptor-3

Details Compositions and methods related to toll-like receptor-3 Compositions and methods related to toll-like receptor-3

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61P 29/00 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2669558

The invention relates to compositions and methods related to Toll-like receptor (TLR) polypeptides. In some embodiments, the invention relates to managing TLR3 related diseases. In further embodiments, the invention relates to methods of preventing and treating inflammation. In some embodiments, the invention relates to antagonists of TLR3, to amino acid sequences that act as dominant negative molecules, and to nucleic acid sequences that encode said amino acid sequences. In additional embodiments, the invention relates to the manipulation of biological materials to evaluate TLR3 activity.

L'invention concerne des compositions et des procédés associés à des polypeptides du récepteur de type Toll (TLR). Dans certains modes de réalisation, l'invention concerne le traitement de maladies liées au TLR3. Dans d'autres modes de réalisation, l'invention concerne des procédés permettant de prévenir et de traiter l'inflammation. Dans certains autres modes de réalisation, l'invention concerne des antagonistes du TLR3, des séquences d'acides aminés agissant comme des molécules négatives dominantes, ainsi que des séquences d'acides nucléiques codant pour ces séquences d'acides aminés. Dans d'autres modes de réalisation, l'invention concerne la manipulation de matières biologiques pour évaluer l'activité du TLR3.

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