C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2531526
The present invention provides methods and compositions relating to fusion proteins comprising multimeric soluble TWEAK receptor fragments and an oligomerization domain. Such fusion proteins are useful for antagonizing the TWEAK receptor and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and inflammatory conditions.
La présente invention concerne des procédés et des compositions ayant trait à des protéines hybrides comprenant des fragments solubles multimériques du récepteur et un domaine d'oligomérisation. De telles protéines hybrides sont utiles en tant qu'antagonistes du récepteur TWEAK et pour le traitement de maladies ou de conditions médiées par l'angiogenèse, telles que des tumeurs solides ou des conditions inflammatoires.
Amgen Inc.
Smart & Biggar
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