Compositions and methods relating to osteoarthritis

Details Compositions and methods relating to osteoarthritis Compositions and methods relating to osteoarthritis

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2439504

The invention provides for one or more polynucleotide sequences that are expressed in chondrocytes from any of the following developmental and disease stages: fetal, normal, mild, ostearthritic, moderate osteoarthritic, marked and osteoarthritic. The invention also relates to arrays and compositions comprising any combination of these polynucleotide sequences. The invention also provides for methods of using the arrays of the invention to diagnose osteoarthritis. The invention also provides for methods of identifying therapeutic agents that alter the level of expression of the polynucleotides of the invention or alter the anabolic level of a chondrocyte.

L'invention concerne une ou plusieurs séquences polynucléotidiques exprimées dans des chondrocytes d'un stade quelconque de développement et de maladie suivant : foetal, normal, ostéoarthrite légère, ostéoarthrite moyenne, ostéoarthrite marquée. La présente invention porte également sur des échantillons et des compositions comprenant une combinaison quelconque de ces séquences polynucléotidiques, sur des procédés pour utiliser ces échantillons dans le diagnostic de l'ostéoarthrite, sur des procédés pour identifier des agents thérapeutiques qui modifient le niveau d'expression des polynucléotides selon l'invention ou qui modifient l'effet anabolisant d'un chondrocyte.

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