A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01)
Patent
CA 2632797
The present invention provides methods for modulating an immune response by administering a composition comprising a Toll-iike receptor agonist and an immune mediator which downregufates the expression of the anti-inflammatory cytokine IL-10 and upregulates the expression of the pro-inflammatory cytokine IL-12. The methods can be used to provide therapeutic treatment for cancerous conditions and infectious diseases.
La présente invention concerne des méthodes de modulation d'une réponse immunitaire par administration d'une composition comprenant un agoniste des récepteurs de type Toll et un médiateur immunitaire qui régule négativement l'expression de la cytokine anti-inflammatoire IL-10 et régule positivement l'expression de la cytokine pro-inflammatoire IL-12. Lesdites méthodes peuvent être utilisées pour fournir un traitement thérapeutique pour des pathologies cancéreuses et des maladies infectieuses.
Jarnicki Andrew
Mills Kingston
Toomey Deirdre
Fasken Martineau Dumoulin Llp
The Provost Fellows And Scholars Of The College Of The Holy And Undivid Ed T
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