Compositions and methods to control angiogenesis with...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/095 (2006.01) A61K 39/10 (2006.01) A61K 39/108 (2006.01) A61K 39/38 (2006.01) A61K 49/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01)

Patent

CA 2615560

The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development.

L'invention porte: sur des compositions comprenant des cuprédoxines, et sur leur utilisation comme inhibiteurs de l'angiogenèse dans des cellules et des tissus de mammifères, et en particulier sur l'angiogenèse accompagnant le développement de tumeurs et en particulier chez l'homme. L'invention porte plus spécifiquement sur des compositions comprenant des cuprédoxines et/ou des peptides constituant des variantes, des dérivés ou des équivalents structurels des cuprédoxines, et capables d'inhiber l'angiogenèse dans des cellules et des tissus de mammifères. Lesdites compositions pouvant être notamment des compositions de peptides ou des préparations pharmaceutiques pouvant servir à traiter tout état pathologique ayant pour symptôme ou cause une angiogenèse inappropriée, et en particulier une angiogenèse inappropriée associée au développement de tumeurs.

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