A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2720677
The invention relates to the field of molecular medicine. In particular, it relates to compositions and methods to enhance the clearance of aberrant cells, e.g. cancer cells or virus-infected cells, by the host's im-mune system. Provided is a composi-tion comprising (i) a therapeutic com-pound that can trigger a host's im-mune effector cells against an aber-rant cell, such as a therapeutic anti-body, and (ii) at least one agent capa-ble of reducing or preventing in-hibitory signal transduction initiated via SIRPalpha.
La présente invention concerne le domaine de la médecine moléculaire. En particulier, elle concerne des compositions et des procédés pour augmenter la clairance de cellules aberrantes, par exemple des cellules cancéreuses ou des cellules infectées par un virus, par le système immunitaire de lhôte. La présente invention concerne une composition comprenant (i) un composé thérapeutique qui peut déclencher des cellules effectrices immunitaires dun hôte contre une cellule aberrante, tel quun anticorps thérapeutique, et (ii) au moins un agent capable de réduire ou prévenir une transduction de signal inhibiteur initiée via SIRPalpha.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Stichting Sanquin Bloedvoorziening
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