A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01)
Patent
CA 2543484
Methods and compositions for modulating an immune response to an immunogenic therapeutic agent are disclosed. One of the disclosed methods comprises administering an effective amount of CTLA-4 to decrease the incidence and/or severity of an immune reaction in conjunction with the administration of a potentially immunogenic substance. Another method contemplates tolerizing a subject to a therapeutic molecule that is or is capable of being immunogenic by the administration of CTLA-4. Various embodiments of CTLA-4 are also disclosed.
L'invention concerne des procédés et des compositions permettant de moduler la réaction immunitaire à un agent thérapeutique immunogène. Un des procédés décrits comporte l'administration d'une quantité efficace de CTLA-4 pour réduire l'incidence et/ou la gravité d'une réaction immunitaire, de façon concomitante à l'administration d'une matière potentiellement immunogène. Un autre procédé vise à rendre le sujet tolérant à l'égard d'une molécule thérapeutique susceptible d'être immunogène, par l'administration de CTLA-4. Diverses formes de CTLA-4 sont également décrites.
Feige Ulrich
Khare Sanjay D.
Amgen Inc.
Smart & Biggar
LandOfFree
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