Compositions and methods to prevent cancer with cupredoxins

Details Compositions and methods to prevent cancer with cupredoxins Compositions and methods to prevent cancer with cupredoxins

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 35/74 (2006.01) A61P 35/00 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2747404

The present invention relates to compositions and methods comprising chemopreventive agents that may be cupredoxin(s) or variants, derivatives and structural equivalents of cupredoxins, and at least one other chemopreventive agent. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The at least one other chemopreventive agent may comprise an antiestrogen such as Tamoxifen. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.

La présente invention concerne des compositions et des procédés qui comprennent des agents chimiopréventifs qui peuvent être une ou plusieurs cuprédoxines ou des variantes, des dérivés et des équivalents structuraux de cuprédoxines, et au moins un autre agent chimiopréventif. Ces compositions peuvent notamment comprendre de l'azurine de Pseudomonas aeruginosa et/ou la région du résidu 50-77 de l'azurine (p28). Le ou les autres agents chimiopréventifs peuvent comprendre un anti-estrogène tel que le Tamoxifène. Les compositions de l'invention peuvent être utilisées pour prévenir le développement de lésions prémalignes dans des cellules, des tissus et des animaux mammaliens, et ainsi prévenir le cancer.

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