Compositions and methods to prevent cancer with cupredoxins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/02 (2006.01) A61K 35/74 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2747192

The present invention discloses methods and materials for killing and/or inhibiting the growth of a cancer cell via preferential entry of a cytotoxic compound. Preferential entry of the cytotoxic compound is accomplished by the use of protein transduction domains derived from cupredoxins, including the p18 and p28 truncations of azurin.

La présente invention concerne des procédés et des matériaux pour tuer et/ou inhiber la croissance d'une cellule cancéreuse par entrée préférentielle d'un composé cytotoxique. L'entrée préférentielle du composé cytotoxique est réalisée par l'utilisation de domaines de transduction de protéine dérivés de cuprédoxines, comprenant les troncatures p18 et p28 d'azurine.

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