Compositions and methods to protect cells by blocking entry...

Details Compositions and methods to protect cells by blocking entry... Compositions and methods to protect cells by blocking entry...

A - Human Necessities

61

K

A61K 31/6615 (2006.01) A61K 38/02 (2006.01) A61P 31/00 (2006.01) C07K 14/44 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2724569

Pathogenic effector proteins which include one or more RxLR, dEER, Pexel or analogous motifs are blocked from entry into plant or animal cells by binding one or more of the motifs with a blocking compound which prevents binding of phosphoinositides or other polar lipids to the motifs which is a prerequisite for translocation of the pathogenic effector proteins into the plant or animal cell. The blocking compounds can take a variety of forms including synthetic peptides or the hydrophilic head-groups of phosphoinositides, phosphatidic acids, phospholipids, or sphingolipids. Suitable blocking compounds can be identified by assays demonstrating binding to RxLR, dEER, Pexel or analogous motifs. In addition, pathogenic effector proteins can be identified by analyzing whether they contain structural RxLR motifs using hidden markov modeling.

L'invention porte sur des protéines effectrices pathogènes qui comprennent un ou plusieurs motifs RxLR, dEER, Pexel ou analogues dont l'entrée dans des cellules végétales ou animales est bloquée par liaison d'un ou plusieurs des motifs avec un composé de blocage qui empêche la liaison de phosphoinositides ou autres lipides polaires aux motifs, qui est un prérequis pour la translocation des protéines effectrices pathogènes dans la cellule végétale ou animale. Les composés de blocage peuvent revêtir diverses formes comprenant des peptides synthétiques ou les groupes de tête hydrophiles de phosphoinositides, acides phosphatidiques, phospholipides ou sphingolipides. Les composés de blocage appropriés peuvent être identifiés par des essais démontrant la liaison aux motifs RxLR, dEER, Pexel ou analogues. De plus, des protéines effectrices pathogènes peuvent être identifiées par analyse du point de savoir si elles contiennent ou non des motifs RxLR structuraux à l'aide d'une modélisation de Markov cachée.

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