Compositions and methods to treat acute myelogenous leukemia

Details Compositions and methods to treat acute myelogenous leukemia Compositions and methods to treat acute myelogenous leukemia

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2758548

Compositions and methods for treating or preventing a hematologic malignancy, such as AML, using an anti-alpha4 antibody in combination with chemotherapy agents in a therapeutically effective amount The method includes administering to the patient a therapeutically effective amount of a composition containing an antagonist of an interaction between an integnn with an alpha4 subunit (VLA-4) and a ligand for this integnn (VCAM-1)

L'invention porte sur des compositions et sur des procédés pour le traitement ou la prévention d'une malignité hématologique, telle qu'un AML, à l'aide d'un anticorps anti-alpha4 en combinaison avec des agents de chimiothérapie dans une quantité thérapeutiquement efficace. Le procédé comprend l'administration au patient d'une quantité thérapeutiquement efficace d'une composition contenant un antagoniste d'une interaction entre une intégrine avec une sous-unité alpha4 (VLA-4) et un ligand pour cette intégrine (VCAM-1).

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