Compositions and methods using microspheres and non-ionic...

A - Human Necessities – 61 – K

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A61K 9/16 (2006.01) A61K 49/04 (2006.01) A61K 49/18 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2607228

The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.

L'invention concerne des compositions et des méthodes de traitement de maladies et de troubles, notamment le cancer et diverses autres maladies dépendant de l'angiogénèse, des mauvaises fonctions vasculaires, des malformations artério-veineuses (AVM), des processus hémorragiques et le traitement de douleur, notamment une douleur relative à une tumeur, par administration médicamenteuse et/ou embolisation thérapeutique, au moyen de microsphères. Plus précisément, l'invention concerne des microsphères renfermant des agents de contraste non ioniques, des compositions renfermant ces microsphères, ainsi que des procédés de préparation et d'utilisation de telles compositions destinées à une thérapie d'embolisation. L'invention concerne également des compositions et des procédés d'utilisation de microsphères détectables destinées à une administration médicamenteuses ciblée, indépendamment du fait que l'embolisation est également nécessaire ou non.

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