C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2451677
The invention features a novel isolated Family B DNA polymerase, a Thermococcus polymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3~ to 5~ exonuclease activity and/or exhibit reduced discrimination against non-conventional nucleotides relative to the wild-type form of the polymerase.
La présente invention concerne une polymérase d'ADN isolée appartenant à la famille B, en l'occurrence une polymérase JDF-3 de Thermococcus, et certaines formes recombinantes mutantes. Les polymérases mutantes de l'invention présentent un déficit d'activité des exonucléases 3' à 5' et/ou font preuve, contre les nucléotides non conventionnels, d'une discrimination inférieure à celle de la forme de type sauvage de la polymérase.
Hansen Connie Jo
Hogrefe Holly
Sorge Joseph A.
Stratagene
Torys Llp
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