Compositions and methods with enhanced therapeutic activity

Details Compositions and methods with enhanced therapeutic activity Compositions and methods with enhanced therapeutic activity

C - Chemistry, Metallurgy

07

C

C07C 43/205 (2006.01) A61K 31/09 (2006.01) A61K 31/6615 (2006.01) A61P 35/00 (2006.01) C07F 9/12 (2006.01)

Patent

CA 2516078

Novel quinone and catechol compositions, compositions containing prodrugs of quinone and catechol compositions, and methods of use for the treatment of solid tumor cancers and other vascular proliferative disorders. The disclosure particularly relates to the discovery of dual activity agents capable of generating both a vascular targeting effect and direct tumor cell cytotoxicity in order to achieve an enhanced anti-tumor response in a patient.

Nouvelles compositions de quinone et de catechol, compositions contenant des promédicaments de compositions de quinone et de catechol et méthodes servant à utiliser ces compositions afin de traiter des cancers à tumeurs solides ou d'autres maladies prolifératives vasculaires. L'invention concerne en particulier la découverte de deux agents actifs capables de générer à la fois un effet de ciblage vasculaire et une cytotoxicité directe par rapport aux cellules tumorales, dans le but d'optimiser la réaction antitumorale chez le patient.

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