Compositions and systems for the regulation of genes

Details Compositions and systems for the regulation of genes Compositions and systems for the regulation of genes

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A01K 67/027 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) C12N 5/16 (2006.01) C12N 15/63 (2006.01) C12N 15/867 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2506798

The present invention provides compositions and methods of modulating or regulating eukaryotic gene expression through the controlled or regulated expression of polynucleotide constructs that encode siRNA or other desired exogenous nucleic acids or proteins. Such constructs, and additional elements of the system may be transfected into the cells of interest and the expression of the siRNA, and hence the expression of the target gene of the siRNA, may be controlled through the administration of a compound to the cell, such as a small molecule or drug. Lentivirus vectors are employed in some embodiments of the invention including the generation of conditional knockdown animals.

L'invention concerne des compositions et des procédés de modulation ou de régulation de l'expression génique eucaryote au moyen de l'expression contrôlée ou régulée de constructions polynucléotidiques qui codent siARN ou d'autres acides nucléiques ou protéines exogènes désirés. Ces constructions et des éléments supplémentaires du système peuvent être transfectés dans les cellules d'intérêt et l'expression de siARN, et par voie de conséquence l'expression du gène cible de siARN, peuvent ainsi être contrôlées par l'administration d'un composé dans la cellule tel qu'une petite molécule ou un médicament. Des vecteurs de lentivirus sont utilisés dans certains modes de réalisation de l'invention dont la génération d'animaux knock-down conditionnels.

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