A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 31/16 (2006.01) A61K 9/00 (2006.01) A61L 15/44 (2006.01) A61L 24/00 (2006.01) A61L 27/54 (2006.01) A61L 29/16 (2006.01)
Patent
CA 2465676
A therapeutic medical article is provided which comprises a medical article, a precursor compound and an activor compound. The medical article is adapted, upon administration to a patient, to release the precursor compound and the activator compound such that the activator compound interacts with the precursor compound and converts the precursor compound into activated form for local delivery. Specific examples of precursor and activator compound pairs include: (a) a nitrosothiol precursor and a nitric oxide donor, (b) plasminogen and plasminogen activator, and (c) fibrinogen and thrombin.
L'invention concerne un article médical thérapeutique comprenant un article médical, un composé précurseur et un composé activateur. Cet article médical est conçu pour, après administration à un patient, libérer le composé précurseur et le composé activateur de façon que le composé activateur interagisse avec le composé précurseur et convertisse ce dernier en une forme activée pour une distribution locale. Des exemples spécifiques de paires de composés précurseur et activateur comprennent notamment: (a) précurseur de nitrosothiol et donneur d'oxyde nitrique, (b) plasminogène et activateur de plasminogène, et (c) fibrinogène et thrombine.
Boston Scientific Limited
Kirby Eades Gale Baker
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