C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61P 11/00 (2006.01)
Patent
CA 2597845
Disclosed herein are compounds, compositions and methods for modulating the expression of IL- 4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-.alpha., airway hyperresponsiveness, and/or pulmonary inflammation.
L'invention concerne des composés, des compositions et des méthodes de modulation de l'expression de IL 4R-.alpha. dans une cellule, un tissu ou chez un animal. Cette invention a aussi pour objet des méthodes de validation cible, ainsi que des utilisations desdits composés et compositions dans la conception d'un médicament destiné à traiter des maladies ou des troubles liés à l'expression d'IL 4R-a, à une hypersensibilité des voies aériennes et/ou à une inflammation pulmonaire.
Crosby Jeffrey R.
Freier Susan M.
Gregory Susan
Karras James G.
Tung David
Isis Pharmaceuticals Inc.
Smart & Biggar
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