Compositions and their uses for gene therapy of bone conditions

Details Compositions and their uses for gene therapy of bone conditions Compositions and their uses for gene therapy of bone conditions

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/50 (2006.01) A61K 31/711 (2006.01) A61K 47/36 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2626394

The present invention provides compositions for the treatment of conditions associated with low' bone density. The compositions comprise a payload molecule that comprises a nucleic acid selected from the group consisting of an oligonucleotide, an antisense construct, a siRNA, an enzymatic RNA, a mRNA, a recombinant DNA construct, a linear DNA fragment, a blocked linear DNA fragment and a mixture thereof ; a payload trapping molecule selected from the group consisting of chitosan, polyehtylenimine, poly-L-lysine, alginate, xanthan, hexadecyltrimenthylammoniumbromide and mixtures thereof ; and a carrier selected from a yeast particle or a yeast glucanmannan particle.

Dans certains modes de réalisation, la présente invention concerne des compositions et des procédés pour traiter des pathologies osseuses qui sont associées à une faible densité osseuse. Dans des modes de réalisation préférés, cette invention concerne des compositions et des procédés pour traiter des pathologies sensibles à l'ostéoprotégérine.

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