Compositions and treatment for multiple sclerosis

Details Compositions and treatment for multiple sclerosis Compositions and treatment for multiple sclerosis

A - Human Necessities

61

K

A61K 38/21 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2189990

The present invention provides compositions and methods for treating multiple sclerosis. Compositions of the invention comprise at least one peptide or modified peptide of myelin basic protein (MBP) which comprise at least one T cell epitope, and IFN-.beta. in an appropriate pharmaceutically acceptable medium for either oral, subcutaneous or intravenous administration. Methods of the inven include treatment of individuals who either have MS or are suspected of being susceptible to MS by administering a therapeutically effective amount of a composition of the invention or by administering in a therapeutic regimen, a composition comprising at least one peptide or modified peptide of MBP which comprises at least one T cell epitope and further administering IFN-.beta..

L'invention concerne des compositions et des procédés pour le traitement de la sclérose en plaques. Lesdites compositions comprennent au moins un peptide ou un peptide modifié de la protéine basale de myéline (MBP) qui comprend au moins un déterminant antigénique de lymphocyte T, et de l'interféron-.beta. dans un véhicule pharmaceutiquement acceptable pour l'administration par voie orale, sous-cutanée ou intraveineuse. Les procédés selon l'invention consistent à traiter des individus souffrant de sclérose en plaques ou sujets à la sclérose en plaques par l'administration d'une dose thérapeutiquement efficace d'une composition de l'invention ou par l'administration, dans le cadre d'un schéma thérapeutique, d'une composition comprenant au moins un peptide ou un peptide modifié de la protéine basale de myéline, qui comprend au moins un déterminant antigénique de lymphocyte T, ainsi que de l'interféron .beta..

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