Compositions and treatment for multiple sclerosis

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/47 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 38/21 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2203629

The present invention provides isolated peptides and combinations of peptides derived form myelin autoantigens such as MBP, MOG, PLP, and MAG suitable for treating multiple sclerosis, including prophylactic and therapeutic compositions and methods for preventing or treating multiple sclerosis. Preferred compositions of the invention comprise at least one isolated, purified peptide, free from all other polypeptides or contaminants, the peptide comprising an amino acid sequence, the myelin autoantigen which has T cell activity. A therapeutic composition of the invention is capable of down regulating the autoantigen specific immune response to the myelin autoantigen in a population of humans suffering from, or susceptible to multiple sclerosis, such that disease symptoms are reduced, eliminated, or reversed and/or the onset or progression of disease symptoms is prevented or slowed. Additionally, compositions and methods of the instant invention when administered in an advanced stage of disease, reverse ongoing paralysis or other signs of disease when administered during the acute phase of disease or prevents relapse when administered during remission.

L'invention concerne des peptides isolés et des combinaisons de peptides dérivés d'autoantigènes de myéline, tels que MBP, MOG, PLP et MAG, convenant au traitement de la sclérose en plaques, y compris des compositions prophylactiques et thérapeutiques et des procédés de prévention ou de traitement de la sclérose en plaques. Des compositions préférées de l'invention comprennent au moins un peptide purifié isolé, exempt de tous autres polypeptides ou contaminants, ce peptide comportant une séquence d'acides aminés de l'autoantigène de myéline possédant une activité de lymphocyte T. Une composition thérapeutique selon l'invention est capable de réguler négativement la réponse immune spécifique de l'autoantigène à l'autoantigène de myéline dans une population humaine atteinte de sclérose en plaques, ou exposée à la sclérose en plaques, de manière à diminuer, éliminer ou inverser les symptômes de la maladie et/ou à prévenir ou à ralentir l'apparition ou la progression de ces symptômes. De plus, ces compositions et ces procédés, quand on les applique à un stade avancé de la maladie, inversent la paralysie en progression ou d'autres signes pathologiques, quand on les administre pendant la phase aiguë de la maladie, ou empêchent la rechute, quand on les administre en période de rémission.

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