Compositions and uses of e3-gp19k for treating diabetes

A - Human Necessities – 61 – K

Patent

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Details

A61K 48/00 (2006.01) A61K 39/235 (2006.01) A61P 3/10 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2653201

A substance for preventing, delaying the onset of, or treating one or more than one autoimmune disease, the substance comprising a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for the autoimmune disease. A method for preventing, delaying the onset of or treating an autoimmune disease in a patient comprising selecting a patient who is susceptible to developing the autoimmune disease, who is developing the autoimmune disease or who has the autoimmune disease and administering to the patient one or more than one dose of a polynucleotide construct comprising a polynucleotide sequence encoding the pro- apoptotic protein BAX and encoding one or more than one autoantigen for an autoimmune disease, or comprising a polynucleotide sequence encoding the adenoviral protein E3-GP19k, or comprising a polynucleotide sequence encoding .DELTA.BCL-2.

L'invention porte sur une substance permettant de prévenir, retarder l'apparition ou traiter une ou plusieurs maladies autoimmunes, la substance étant constituée d'une construction polynucléotidique contenant une séquence polynucléotidique codant la protéine proapoptotique BAX et codant un ou plusieurs auto-antigènes induisant une maladie autoimmunitaire. L'invention porte également sur une méthode permettant de prévenir, de retarder l'apparition ou de traiter une maladie autoimmune chez un patient, la méthode comprenant le choix d'un patient qui est susceptible de développer une maladie autoimmune, qui est en train de développer une maladie autoimmune ou qui est atteint d'une maladie autoimmune et l'administration au patient d'une ou de plusieurs doses d'une contruction polynucléotidique contenant une séquence polynucléotidique codant la protéine proapoptotique BAX et codant un ou plusieurs autoantigènes induisant une maladie autoimmune, ou contenant une séquence polynucléotidique codant la protéine adénovirale E3-GP19k, ou contenant une séquence polynucléotidique codant DELTA BCL-2.

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