Compositions and uses thereof for the treatment of wounds

Details Compositions and uses thereof for the treatment of wounds Compositions and uses thereof for the treatment of wounds

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2662374

The present invention provides a topical composition comprising (i) an amount of an AP-1 signaling inhibitor sufficient to reduce, delay or prevent apoptosis and/or necrosis induced by dermal wounding and/or to induce and/or enhance proliferation of a cell; and (ii) a suitable carrier or excipient e.g., a topical carrier or excipient or other carrier or excipient for dermal application. For example, the AP-1 signaling inhibitor is a peptide analog comprising the sequence set forth in SEQ ID NO: 104. The present invention also provides a method of treating a dermal wound comprising topically administering said topical composition to a subject suffering from a dermal wound.

L'invention concerne une composition topique qui comprend (i) une quantité d'inhibiteurs de signalisation AP-1 suffisante à réduire, retarder ou prévenir l'apoptose et/ou la nécrose induite par des plaies cutanées et/ou à induire et/ou améliorer la prolifération d'une cellule; et (ii) un support ou un excipient approprié par ex., un support ou un excipient topique ou un autre support ou excipient pour application cutanée. L'inhibiteur de signalisation AP-1 consiste, par exemple, en un analogue peptidique qui comprend la séquence formulée dans SEQ ID NO: 104. Cette invention concerne également un procédé destiné à traiter une plaie cutanée par administration topique de cette composition topique à un patient ayant une plaie cutanée.

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