A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/12 (2006.01) A61K 9/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2751460
The invention relates to composition and a method of using the composition for modulating proliferation, invasive-ness, the expression of a biomarker of an abnormal cell, of reducing the risk of a patient cell becoming abnormal, or of modulating proliferation of a carcinoma-associated fibroblast or of a tumor- associated macrophage. The invention also relates to a method of culturing the composition to produce molecules that modulate abnormal cell proliferation, invasiveness, or metastasis. The composition comprises a biocompatible matrix and cells engrafted thereon.
L'invention porte sur une composition et sur un procédé d'utilisation de la composition pour moduler la prolifération, le caractère invasif, l'expression d'un biomarqueur d'une cellule anormale, de réduction du risque qu'une cellule de patient devienne anormale, ou de modulation de la prolifération d'un fibroblaste associé à un carcinome ou d'un macrophage associé à une tumeur. L'invention porte également sur un procédé de culture de la composition pour produire des molécules qui modulent la prolifération, le caractère invasif ou la métastase de cellules anormales. La composition comprend une matrice biocompatible et des cellules greffées sur celle-ci.
Cardoso Angelo Manuel de Almeida
Edelman Elazer R.
Franses Joseph W.
Nugent Helen Marie
Massachusetts Institute Of Technology
Mbm Intellectual Property Law Llp
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