Compositions based on amino acids for improving the...

A - Human Necessities – 61 – K

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A61K 31/198 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2448745

Compositions based on amino acids are described, for improving the myocardial ventricular function in patients suffering from diabetes, particularly but not exclusively II type diabetes. The compositions according to the invention comprise up to 75% of the branched chain amino acids leucine, isoleucine and valine, as active ingredients. Preferably, the compositions also comprise, as further active ingredients, up to 50 % of threonine and lysine. Other essential amino acids are preferably also provided, in particular methionine, phenylalanine, histidine, tryphtophan, as well as non essential amino acids, in particular tyrosine and/or cyst(e)ine (i.e., cystine and cysteine). Other amino acids can be added, provided that their sum is in a percentage being lower than 20 % with respect to the other active ingredients, and less than 10 % for each single amino acid.

L'invention concerne des compositions à base d'acides aminés, destinées à améliorer la fonction ventriculaire du myocarde chez des patients souffrant du diabète, en particulier, mais sans en exclure d'autres, du diabète de type II. Ces compositions renferment jusqu'à 75 % d'acides aminés à chaîne ramifiée leucine, isoleucine et valine, utilisés comme ingrédients actifs. De préférence, ces compositions renferment également jusqu'à 50 % de thréonine et de lysine, utilisés comme ingrédients actifs supplémentaires. De préférence, ces compositions renferment également d'autres acides aminés essentiels, en particulier de la méthionine, de la phénylalanine, de l'histidine, du tryphtophan, ainsi que des acides aminés non essentiels, en particulier de la tyrosine et/ou de la cyst(é)ine (c'est-à-dire de la cystine et de la cystéine). D'autres acides aminés peuvent également être utilisés, à condition que la somme de ces acides aminés représente moins de 20 % par rapport aux autres ingrédients actifs, et moins de 10 % pour chaque acide aminé.

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