Compositions biphasiques injectables, notamment utiles en...

A - Human Necessities – 61 – L

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A61L 27/52 (2006.01) A61L 27/16 (2006.01) A61L 27/20 (2006.01) A61L 27/22 (2006.01) A61L 27/26 (2006.01) A61L 27/44 (2006.01) A61L 31/04 (2006.01) A61L 31/12 (2006.01) A61L 31/14 (2006.01)

Patent

CA 2335928

The invention concerns: biocompatible diphasic compositions, comprising a dispersed phase suspended in a continuous phase; a method for preparing said compositions; a filling material, useful in reparative and plastic surgery based on said diphasic compositions. The invention is characterised in that said diphasic composition dispersed phase consists of particles of at least a (co)polymer hydrogel obtained by polymerising and crosslinking acrylic acid and/or methacrylic acid and/or at least a derivative of said acids. Advantageously, said diphasic composition continuous phase is a polymer hydrogel selected among hyaluronic acid, its salts and a mixture of its salts, advantageously consisting of a sodium hyaluronate, said polymer being crosslinked.

La présente invention a pour objet: des compositions biphasiques biocompatibles, comprenant une phase dispersée en suspension dans une phase continue; un procédé de préparation desdites compositions; un matériau de comblement, utile en chirurgie réparatrice et en chirurgie esthétique, à base desdites compositions biphasiques. De façon caractéristique, la phase dispersée desdites compositions biphasiques consiste en des particules d'au moins un hydrogel d'un (co)polymère obtenu par polymérisation et réticulation de l'acide acrylique et/ou de l'acide méthacrylique et/ou d'au moins un dérivé desdits acides. De façon particulièrement avantageuse, la phase continue desdites compositions est un hydrogel d'un polymère choisi parmi l'acide hyaluronique, ses sels et mélange de ses sels, consistant avantageusement en un hyaluronate de sodium; ledit polymère étant réticulé.

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