Compositions comprising 1-substituted azacycloalkanes

Details Compositions comprising 1-substituted azacycloalkanes Compositions comprising 1-substituted azacycloalkanes

A - Human Necessities

61

K

167/159, 167/208

A61K 47/22 (2006.01) A01N 25/00 (2006.01) A01N 37/32 (2006.01) A01N 43/46 (2006.01) A61K 31/00 (2006.01) C05G 3/00 (2006.01) C07D 227/02 (2006.01)

Patent

CA 1293192

ABSTRACT OF THE DISCLOSURE This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula Image wherein each X, Y and Z may represent oxygen, sulfur or two hydrogen atoms, provided however that, when Z represents two hydrogen atoms, both X and Y represent oxygen or sulfur and when Z represents oxygen or sulfur at least one of X and Y must represent oxygen or sulfur; m is 2-6; R' is H or a lower alkyl group having 1-4 carbon atoms; n is 0-17 and R is -CH3, Image or Image wherein R'' is H or halogen in an amount effective to enhance the penetration of the physiologically-active agent through the skin or other membrane of the body of an animal.

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