A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 9/50 (2006.01) A61K 31/60 (2006.01)
Patent
CA 2578714
Compositions comprising 5-amino-2-hydroxybenzoic acid (5-amino salicylic acid, mesalamine) and a reducing sugar, e.g., lactose, undergo the Maillard and other chemical reactions and produce, in the case of lactose, a degradant 5-[2- Formyl-5-(hydroxymethyl)-1H-pyrrol-1-y]-2-hydroxybenzoic acid. Inventors have developed means to contain and/or reduce the formation of degradants of 5- amino-2-hydroxybenzoic acid.
L'invention concerne des compositions contenant de l'acide 5-amino-2-hydroxybenzoïque (acide 5-amino salicylique, mésalamine) et un sucre de réduction, par exemple, le lactose, soumises à une réaction de Maillard et à d'autres réactions chimiques, et produisant, dans le cas du lactose, un acide 5-[2-Formyl-5-(hydroxyméthyl)-1H-pyrrol-1-y]-2-hydroxybenzoïque de dégradation. L'invention concerne également des moyens destinés à contenir et/ou à réduire la formation d'agents de dégradation de l'acide 5-amino-2-hydroxybenzoïque.
Kaczanowski Matt John
Redman-Furey Nancy Lee
Trombley Kurt Franklin
Williams Thomas Daniel
The Procter & Gamble Company
Torys Llp
Warner Chilcott Company Llc
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