A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/34 (2006.01) A61K 9/107 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 38/27 (2006.01) A61K 38/28 (2006.01) A61K 38/43 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01)
Patent
CA 2319057
This invention relates to a copolymer pharmaceutical composition useful in oral administration of a number of biological agents or protein, peptide, or derivatives thereof, and a poly(oxyethylene)-poly(oxypropylene) block copolymer. The composition for the delivery of biologically active agents comprises a mixture of poly(oxyethene)--poly(oxypropylene) block copolymers and at least one biologically active agent, wherein the mixture comprises at least one block copolymer with ethylene oxide content of less than 50% and at least one block copolymer with ethylene oxide content of more than 50%. The compositions are useful in the oral delivery of numerous agents and are particularly effective in the delivery of biologically active agents and in reversing resistance to a biological agent.
L'invention concerne des compositions copolymères pour administration par voie orale comportant un agent biologique ou une protéine, un peptide ou un dérivé de ceux-ci ainsi qu'un polymère séquencé poly(oxyéthylène)-poly(oxypropylène). Ces compositions peuvent servir à administrer de nombreux agents par voie orale. L'invention comprend également des méthodes de traitement utilisant ces compositions.
Alakhov Valery Y.
Batrakova Elena V.
Kabanov Alexander V.
Deeth Williams Wall Llp
Supratek Pharma Inc.
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