Compositions comprising a bactericidal/permeability...

A - Human Necessities – 61 – K

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Details

A61K 38/17 (2006.01) A61K 35/14 (2006.01) A61L 27/00 (2006.01) A61L 27/34 (2006.01) A61L 29/00 (2006.01) A61L 29/08 (2006.01) A61L 31/00 (2006.01) A61L 31/10 (2006.01) B01D 15/08 (2006.01) C07K 14/47 (2006.01) G01N 33/569 (2006.01) G01N 33/92 (2006.01) A61K 38/00 (2006.01) F02B 75/02 (2006.01)

Patent

CA 2119262

This invention provides a composition comprising a Bactericidal/Permeability Increasing Protein and a lipid carrier, and a method of forming said composition. This invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a Bactericidal/Permeability Increasing Protein and a pharmaceutically acceptable lipid carrier, and a method of forming said pharmaceutical composition. This invention further provides a method of detecting and a method of quantitative- ly determining the amount of lipopolysaccharide in a sample. This invention further provides a method of coating a surgical tool with a Bactericidal/Permeability Increasing Protein and a method of coating an implantable, invasive device with a Bactericidal/ Permeability Increasing Protein. This invention further provides a method of decontaminating a fluid containing lipopolysaccha- ride prior to administration of the fluid into a subject. This invention further provides a method of treating a subject suffering from an endotoxemia-related disorder. Finally, this invention provides a method of preventing endotoxemia in a subject.

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