Compositions comprising a combination of ccr5 and cxcr4...

Details Compositions comprising a combination of ccr5 and cxcr4... Compositions comprising a combination of ccr5 and cxcr4...

A - Human Necessities

61

K

A61K 31/506 (2006.01) A61K 31/496 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 31/18 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2629037

A composition including a CXCR4 antagonist and a CCR5 antagonist represented by formula I or II: or an acceptable salt, solvate or ester thereof. The GXCR4 antagonist includes at least one of AMD-070. CS-3955, KRH-1 120, KRH-2731, and KRH-1636. These compositions are used to manufacture medicaments for the treatment of HIV infections.

La présente invention concerne une composition comprenant un antagoniste CXCR4 et un antagoniste CCR5 représentés par la formule I ou II : ou un sel, solvate ou ester dérivés acceptables. L'antagoniste CXCR4 comprend au moins un AMD-070, CS-3955, KRH-1120, KRH-2731 et KRH-1636 et KS-3104.

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