C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2504929
The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
La présente invention concerne des compositions comprenant au moins un composé oligomérique, lequel comprend un motif de substitution et une région complémentaire d'une cible acide nucléique. Ces compositions conviennent pour cibler des molécules d'acide nucléique et pour moduler l'expression d'un ou de plusieurs gènes. Dans un mode de réalisation préféré de l'invention, les compositions s'hybrident avec une partie d'un ARN cible entraînant ainsi une perte de fonction normale de cet ARN cible. Cette invention concerne aussi des techniques de modulation de l'expression génique.
Allerson Charles
Baker Brenda F.
Bhat Balkrishen
Eldrup Anne B.
Griffey Richard H.
Isis Pharmaceuticals Inc.
Smart & Biggar
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