Compositions comprising an hiv protease inhibitor

Details Compositions comprising an hiv protease inhibitor Compositions comprising an hiv protease inhibitor

C - Chemistry, Metallurgy

07

D

C07D 277/06 (2006.01) A61K 31/425 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2547404

The present invention relates to pharmaceutical compositions comprising amorphous (4R)-N-allyl-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2- methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-1,3-thiazolidine-4- carboxamide, or a pharmaceutically acceptable salt or solvate thereof, their methods of preparation, their use in inhibiting the HIV protease enzyme, and their use in the manufacture of a medicament for the treatment HIV-infected mammals, such as humans.

La présente invention concerne des compositions pharmaceutiques comportant du (4R)-N-allyl-3-{(2S, 3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxamide amorphe, ou un sel ou un solvate pharmaceutiquement acceptable de ce dernier, leurs procédés de préparation, leur utilisation pour l'inhibition de la protéase du VIH, et leur utilisation dans la fabrication d'un médicament pour le traitement de mammifères présentant une infection au VIH, tels que l'être humain.

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