C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/50 (2006.01) A61K 38/48 (2006.01) A61K 38/49 (2006.01) C12N 9/48 (2006.01) C12N 9/68 (2006.01) C12N 9/72 (2006.01)
Patent
CA 2352477
The present invention relates to one or more compositions that inhibit the proliferation and/or migration of endothelial cells. The compositions contain a kringle 5 region of plasminogen and/or Angiostatin. If two separate compositions are used, one containing a kringle 5 region of plasminogen, or a biologically active portion thereof, and the other containing Angiostatin, the compositions may be administered sequentially or simultaneously. The compositions are useful to treat angiogenic associated disorders.
L'invention concerne une ou plusieurs compositions qui inhibent la prolifération et/ou la migration des cellules endothéliales. Ces compositions contiennent une région kringle 5 du plasminogène et/ou de l'angiostatine. Lors de l'utilisation de deux compositions distinctes dont l'une contient une région 5 du plasminogène, ou une portion biologiquement active de celle-ci, et l'autre contient de l'angiostatine, les compositions peuvent être administrées de manière successive ou simultanée. Ces compositions sont utiles pour traiter les troubles liés à l'angiogenèse.
Ji Richard-Weidong
Kondri Mohammand E.
Trail Pamela A.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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