Compositions comprising antibodies and methods of using the...

Details Compositions comprising antibodies and methods of using the... Compositions comprising antibodies and methods of using the...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 49/04 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2545856

The present invention is directed to compositions of one or more nanoparticulate active agents, at least one PEG-derivatized surface stabilizer, and at least one antibody or fragment thereof, and methods of using such compositions for targeting delivery of the one or more active agents to a desired site. The one or more active agents preferably have a particle size of about 2 microns or less. The targeted delivery can be used, for example, for disease sensing, imaging, or drug delivery.

L'invention concerne des compositions comprenant un ou plusieurs agents actifs nanoparticulaires, au moins un stabilisant de surface dérivé du PEG et au moins un anticorps ou un fragment de celui-ci ; et des procédés d'utilisation de ces compositions pour administrer de façon ciblée le(s) agent(s) actif(s) dans un site voulu. La taille des particules du ou des agents actifs est de préférence égale ou inférieure à environ 2 microns. On utilise une administration ciblée pour, par exemple, détecter des maladies, administrer des médicaments ou mettre en oeuvre une imagerie.

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