Compositions comprising calcium citrate malate and methods...

A - Human Necessities – 61 – K

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A61K 9/14 (2006.01) A61K 31/19 (2006.01) A61K 33/06 (2006.01)

Patent

CA 2661062

A process for producing a calcium citrate malate composition by the steps of: combining a calcium source, a citrate source, a malate source and water to form a calcium citrate malate mixture. The mixture is reacted until reaching a peak temperature of from about 45°C to about 70°C, and then cooled at a rate of from about 1°C/minute to about 4°C/minute to reach a final temperature of less than about 40°C. A calcium citrate malate precipitate is formed and then dried to obtain the calcium citrate malate composition.

L'invention porte sur un procédé de production d'une composition de citrate-malate de calcium comprenant les étapes suivantes: combinaison d'une source de calcium, d'une source de citrate d'une source de malate et d'eau pour former un mélange de calcium, citrate, et malate; réaction du mélange en le portant à une température de pointe comprise entre environ 450°C et environ 700°C; refroidissement à raison d'environ l°C/minute à environ 4°C/minute pour atteindre une température finale de moins d'environ 400°C; formation d'un précipité de citrate-malate de calcium; et séchage du précipité pour obtenir ladite composition.

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