Compositions comprising carisoprodol and methods of use thereof

Details Compositions comprising carisoprodol and methods of use thereof Compositions comprising carisoprodol and methods of use thereof

A - Human Necessities

61

K

A61K 31/27 (2006.01) A61K 9/52 (2006.01) A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61K 31/407 (2006.01) A61P 21/00 (2006.01) A61P 29/00 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2677076

The present invention provides compositions comprising carisoprodol or pharmaceutically acceptable salts, esters or derivatives thereof. In certain embodiments, the invention provides pharmaceutical compositions comprising the skeletal muscle relaxant carisoprodol and one or more additional active agents, such as one or more nonsteroidal antiinflammatory drugs (NSAIDs). The invention further provides methods of use of such compositions in preventing, alleviating and/or treating musculoskeletal pain, muscle spasms, or other non-malignant painful conditions including methods in which the circulating levels of the active pharmaceutical form of carisoprodol are controlled by use of extended- or controlled-release formulations or by strict control of dosage regimen, so as to reduce the level of somnolence observed with other muscle relaxant compositions.

L'invention concerne des compositions comprenant du carisoprodol ou des sels, des esters ou des dérivés pharmaceutiquement acceptables de ceux-ci. Selon certains modes de réalisation, l'invention fournit des compositions pharmaceutiques comprenant du carisoprodol relaxant les muscles du squelette, et un ou plusieurs agents actifs supplémentaires, tels qu'un ou plusieurs médicaments anti-inflammatoires non stéroïdiens (AINS). L'invention fournit en outre des procédés d'utilisation de telles compositions pour empêcher, alléger et/ou traiter une douleur musculo-squelettique, des spasmes musculaires, ou d'autres états douloureux non malins, y compris des procédés dans lesquels les niveaux circulants de la forme pharmaceutique active de carisoprodol sont contrôlés au moyen de formulations à libération prolongées ou contrôlée, ou par un contrôle strict d'un régime de dosage, afin de réduire le niveau de somnolence observé avec d'autres compositions de relaxation musculaire.

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