Compositions comprising cytotoxic agent and permeation...

Details Compositions comprising cytotoxic agent and permeation... Compositions comprising cytotoxic agent and permeation...

A - Human Necessities

61

K

167/218

A61K 9/06 (2006.01) A61K 31/505 (2006.01) A61K 47/10 (2006.01) A61K 47/22 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2038969

ARC 1800 COMPOSITIONS COMPRISING CYTOTOXIC AGENT AND PERMEATION ENHANCERS ABSTRACT OF THE DISCLOSURE The present invention is directed to a composition of matter for the percutaneous administration of a cytotoxic agent, and particularly to the percutaneous administration of 5-fluorouracil. The composition comprises, in combination, the cytotoxic agent to be administered and a permeation-enhancing mixture that includes a lower alkanol, propylene glycol or a mixture of polyethylene glycols, a third permeation enhancer and, optionally, a covehicle. The invention is also directed to a method for treating malignant and non-malignant skin disorders and comprises applying to an area of skin affected by a skin disorder, a therapeutically effective amount of the composition of this invention.

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