Compositions comprising glycosaminoglycan and nonsteroidal...

A - Human Necessities – 61 – K

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Details

A61K 31/726 (2006.01) A61K 31/18 (2006.01) A61K 31/196 (2006.01) A61K 31/405 (2006.01) A61K 31/727 (2006.01) A61K 31/728 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2553781

Pharmaceutical compositions comprising of glycosaminoglycan or salts thereof, preferably chondroitin or salts thereof, more preferably chondroitin sulphate, and nonsteroidal anti-inflammatory drug(s) or salts thereof, optionally with pharmaceutically acceptable excipient(s) are described. The compositions of the present invention provide gastrosparing effect in conditions where nonsteroidal anti-inflammatory drug(s) or their salts are used, particularly in mammals. Also provided are process for the manufacture of such novel compositions and method to minimize the nonsteroidal anti-inflammatory drug(s) induced gastric toxicity.

L'invention concerne des compositions pharmaceutiques comprenant du glycosaminoglycane ou des sels de celui-ci, de préférence de la chondroïtine ou des sels de celle-ci, de préférence encore du sulfate de chondroïtine, et un ou plusieurs médicaments anti-inflammatoires nonstéroïdiens ou des sels de ceux-ci, éventuellement avec un ou plusieurs excipients pharmaceutiquement acceptables. Ces compositions produisent un effet d'épargne gastrique dans des conditions où des médicaments anti-inflammatoires nonstéroïdiens ou leur sels sont utilisés, en particulier chez les mammifères. L'invention concerne également un processus de fabrication de ces nouvelles compositions ainsi qu'un procédé permettant de minimiser la toxicité gastrique induite par des médicaments anti-inflammatoires nonstéroïdiens.

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