Compositions comprising hdac inhibitors and methods of their...

Details Compositions comprising hdac inhibitors and methods of their... Compositions comprising hdac inhibitors and methods of their...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 31/165 (2006.01) A61P 9/04 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2743701

The invention provides compositions of histone deacetylase (HDAC) inhibitors and progenitor cells useful for treating heart failure in a subject. The invention also provides methods of restoring progenitor cell function to aged progenitor cells and methods for enhancing progenitor cell proliferation and/or differentiation using HDAC inhibitors.

Cette invention concerne des compositions d'inhibiteurs d'histone désacétylase (HDAC) et de cellules progénitrices utilisées pour traiter l'insuffisance cardiaque chez un sujet. Cette invention concerne également des procédés permettant de réparer la fonction des cellules progénitrices dans des cellules progénitrices âgées ainsi que des procédés permettant d'améliorer la différentiation et/ou la prolifération des cellules progénitrices au moyen des inhibiteurs HDAC

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