Compositions comprising heparin and soluble tnf receptors...

A - Human Necessities – 61 – K

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A61K 38/19 (2006.01) A61K 31/727 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2322229

The bioactivity of TNF is inhibited by administering heparin or a derivative thereof along with a soluble TNF receptor. The heparin or derivative thereof can be administered simultaneously with the soluble TNF receptor, either in separate compositions or in compositions containing both heparin or a derivative thereof and at least one soluble TNF receptor. The heparin or derivative may also be administered without the soluble TNF receptor and still effect some amount of inhibition of TNF bioactivity.

La bioactivité du TNF est inhibée par administration de l'héparine ou d'un dérivé de l'héparine en combinaison avec un récepteur du TNF soluble. L'héparine ou son dérivé peut être administrée simultanément avec le récepteur du TNF soluble, soit dans des compositions distinctes, soit dans des compositions contenant l'héparine ou un dérivé de l'héparine et au moins un récepteur du TNF soluble. L'héparine ou son dérivé peut également être administrée sans le récepteur du TNF soluble et inhiber dans une certaine mesure la bioactivité du TNF.

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