Compositions comprising lipoxygenase inhibitors and...

A - Human Necessities – 61 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 47/40 (2006.01) A61K 31/381 (2006.01)

Patent

CA 2626122

The present invention is directed to formulations of inclusion complexes of lipoxygenase inhibitors and cyclodextrins having a therapeutically effective concentration of the lipoxygenase inhibitor, methods of making the same and methods of treating disease states using the same. Forming cyclodextrin complexes permits the enhancement of the aqueous solubility of lipoxygenase inhibitors which allows higher concentrations of the lipoxygenase in solution. Aqueous formulations of lipoxygenase inhibitors-cyclodextrin complexes are suitable for parenteral or oral administration for treating and/or preventing inflammatory disease states. The aqueous formulations can be lyophilized to prolong storage stability, assist in oral administration and/or provide for convenient and economical packaging.

La présente invention concerne des préparations de complexes d'inclusion d'inhibiteurs de lipoxygénase et de cyclodextrines présentant une concentration thérapeutiquement efficace en inhibiteur de lipoxygénase, des procédés de fabrication de ces préparations ainsi que des méthodes destinées à traiter des pathologies au moyen de celles-ci. La formation de complexes de cyclodextrine permet d'augmenter la solubilité aqueuse des inhibiteurs de lipoxygénase, ce qui permet d'obtenir des concentrations accrues en lipoxygénase dans la solution. Les préparations aqueuses de complexes inhibiteurs de lipoxygénase/cyclodextrine peuvent être administrées par voie parentérale ou orale pour le traitement et/ou la prévention de pathologies inflammatoires. Ces préparations aqueuses peuvent être lyophilisées en vue d'une prolongation de la stabilité au stockage, d'une facilitation de l'administration orale et/ou de l'obtention d'un conditionnement pratique et économique.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Compositions comprising lipoxygenase inhibitors and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions comprising lipoxygenase inhibitors and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions comprising lipoxygenase inhibitors and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1499488

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.