Compositions comprising macrolide t-cell immunomodulators or...

Details Compositions comprising macrolide t-cell immunomodulators or... Compositions comprising macrolide t-cell immunomodulators or...

A - Human Necessities

61

K

A61K 31/436 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2521260

Highly compatible or synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and an antibacterial such as sulfasalazin, ciprofloxacin, ofloxacin, erythromycin or gentamycin, optionally with a further pharmaceutically active agent, especially a retinoid, are provided, which are useful in particular in the treatment of diseases involving bacterial or suspected or anticipated bacterial infection, for immunomodulation or immunosuppression in conditions in which bacterial or suspected or anticipated bacterial colonisation of e.g. the skin plays a role, such as atopic, contact and seborrhoeic dermatitis, eczema, psoriasis, acne, rosacea, post-peel, skin burning, itching, or IBD, and in situations of bacterial resistance.

L'invention concerne des complexes hautement compatibles ou médicamenteux d'un immunomodulateur ou immunosuppresseur macrolide de lymphocyte T tel que 33-épichloro-33-désoxyascomycine et un antibactérien tel que la sulfasalazine, la ciprofloxacine, l'ofloxacine, l'érythromycine ou la gentamycine, éventuellement avec un autre principe pharmaceutiquement actif, en particulier un rétinoïde. Ces complexes sont utiles dans le traitement de maladies impliquant une infection bactérienne ou soupçonnée comme telle ou prévue pour l'immunomodulation ou l'immunosuppression dans des conditions où la colonisation bactérienne ou soupçonnée comme telle ou prévue de la peau, par exemple, joue un rôle, telle que dermatite atopique, de contact et séborrhéique, eczéma, psoriasis, acné, rosacée, post-peel, brûlures de la peau, démangeaisons, ou affections intestinales inflammatoires (IBD), et dans des situations de résistance bactérienne.

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