A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 21/00 (2006.01)
Patent
CA 2730923
Disclosed herein are compositions and methods for treatment of muscle dysfunction (including sarcopenia) and other diseases involving skeletal musle, including age-related muscle dysfunction. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the treatment of skeletal musle disorder, including those related to thr normal aging process. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with altered intracellular Ca2+ reulgation and disrupted membrane structure that occurs when the expression levels of MG29 are reduced.
La présente invention concerne des compositions et des procédés pour le traitement dun dysfonctionnement musculaire (comprenant la sarcopénie) et dautres maladies concernant les muscles squelettiques, comprenant un dysfonctionnement musculaire lié au vieillissement. De plus, linvention concerne des compositions thérapeutiques comprenant des nucléotides et/ou des polypeptides de linvention en combinaison avec un véhicule pharmaceutiquement acceptable, où la composition facilite le traitement dun trouble des muscles squelettiques, comprenant ceux liés au processus de vieillissement normal. De plus, linvention concerne le traitement et/ou la prévention détats pathologiques associés à une régulation de Ca2+ intracellulaire altérée et à une structure de membrane perturbée qui se produit lorsque les taux dexpression de MG29 sont réduits.
Ma Jianjie
Weisleder Noah
Fetherstonhaugh & Co.
University Of Medicine And Dentistry Of New Jersey
LandOfFree
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