Compositions comprising nanoparticulate meloxicam and...

A - Human Necessities – 61 – K

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Details

A61K 31/5415 (2006.01) A61K 9/54 (2006.01) A61K 31/485 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2660650

The invention relates to a compositions comprising a nanoparticulate meloxicam composition in combination with a multiparticulate modified release hydrocodone composition that, upon administration to a patient, delivers a hydrocodone in a bimodal or multimodal manner. The multiparticulate modified release composition comprises a first component and at least one subsequent component; the first component comprising a first population of hydrocodone - comprising particles and the at least one subsequent component comprising a second population of hydrocodone-comprising particles, wherein the combination of the components exhibit a bimodal or multimodal release profile. The invention also relates to a solid oral dosage form comprising such a combination composition.

Cette invention concerne des compositions comprenant une composition de meloxicam nanoparticulaire combinée à une composition d'hydrocodone multiparticulaire à libération modifiée qui, après administration à un patient, libère un hydrocodone sous une forme bimodale ou multimodale. La composition multiparticulaire à libération modifiée comprend un premier constituant et au moins un constituant subséquent. Le premier constituant comprend une première population de particules contenant de l'hydrocodone; et le ou les constituants subséquents comprennent une seconde population de particules contenant de l'hydrocodone. Ces constituants combinés présentent un profil de libération bimodale ou multimodale. L'invention concerne en outre une forme posologique orale solide comprenant cette composition combinée.

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