C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2410864
Modulators of NET-4 are provided that reduce the expression or biological activities of NET-4 or the expression of NET-4mRNA in a mammalian cell. NET-4 modulators include antisense molecules, NET-4 modulators find use in compositions and methods for decreasing NET-4 gene expression as well as methods for inhibiting the proliferation of mammalian cells, including tumor cells, and methods for treating neoplastic diseases.
L'invention concerne des modulateurs de NET-4 permettant de réduire l'expression ou les activités biologiques de NET-4 ou l'expression de l'ARNm de NET-4 dans une cellule de mammifère. Les modulateurs de NET-4 comprennent des molécules antisens, des ribozymes, des anticorps et des fragments d'anticorps, des protéines et des polypeptides ainsi que de petites molécules. Les modulateurs de NET-4 trouvent une utilisation dans des compositions et dans des procédés permettant de diminuer l'expression génétique de NET-4, dans des procédés d'inhibition de la prolifération cellulaire chez des mammifères, y compris de cellules tumorales, ainsi que dans des méthodes de traitement de maladies néoplastiques.
Jefferson Anne B.
Randazzo Filippo
Reinhard Christoph
Winter Jill A.
Borden Ladner Gervais Llp
Chiron Corporation
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