Compositions comprising nucleic acids incorporated in...

Details Compositions comprising nucleic acids incorporated in... Compositions comprising nucleic acids incorporated in...

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 9/16 (2006.01) A61K 47/02 (2006.01) C01F 7/00 (2006.01)

Patent

CA 2395742

The invention concerns compositions comprising at least a nucleic acid and a mineral particle having an interchangeable foliate structure, the method for preparing them and their uses for in vivo, in vitro and/or ex vivo nucleic acid transfection. Said mineral particles preferably correspond to general formula (I): [M?II¿¿1-x?M?III¿¿x?(OH)¿2?]?x+¿[X?m-¿¿x/m? nH¿2?O]?x-¿.

La présente invention se rapporte à des compositions comprenant au moins un acide nucléique et une particule minérale ayant une structure à feuillets échangeables, leur procédé de préparation et leurs applications pour la transfection in vivo, in vitro et/ou ex vivo d'acides nucléiques. Préférentiellement, lesdites particules minérales sont de formule générale (I): [MII1-xMIIIx(OH)2]x+[Xm-x/m .nH2O]x-.

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