Compositions comprising optimized her1 and her3 multimers...

Details Compositions comprising optimized her1 and her3 multimers... Compositions comprising optimized her1 and her3 multimers...

C - Chemistry, Metallurgy

07

K

C07K 14/71 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2702740

The invention provides for compositions comprising engineered Her3 multimers with improved binding affinity. Such multimers include, but are not limited to, Herl/Her 3 heterodimers in which the Her3 ligand binding domain has been optimized to increase binding to Her3. The composition also can include mixtures of Her 1 homodimers, Her 3 homodimers, and Her 1/Her 3 heterodimers.

L'invention porte sur des compositions comprenant des multimères Her3 synthétisés par génie génétique avec une affinité de liaison améliorée. De tels multimères comprennent, mais sans y être limités, des hétérodimères Her1/Her3 dans lesquels le domaine de liaison au ligand Her3 a été optimisé pour augmenter la liaison à Her3. La composition peut également comprendre des mélanges d'homodimères Her1, d'homodimères Her3 et d'hétérodimères Her1/Her3.

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